I am trying to work with sim42 these days. first I found this site:
It was a really good result. I downloaded Python 2.7 and numpy :

Tow ways I tried the CommandInterface :

start dos
cd c:/Python27/
python C:/sim42/sim/cmd/

from python GUI
Run by F5

Both way I am getting the following warning:
failed to set up code optimization
Could not load thermo provider VirtualMaterials

Then I found sim42full_2.0.0.0 from:

using this version, I could run examples. Although it works only with PK package.
if the simulation is saved in sami.tst then :
read C:/sami.tst

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